Therapy intervention at an early age has been proven to be one of the most effective ways to improve the quality of life for individuals with Kleefstra Syndrome. The early intervention team may consist of therapists and medical specialists trained to help develop skills such as:

  • Cognitive skills (thinking, learning, problem-solving)
  • Communication skills (gesturing, talking, listening, understanding)
  • Physical and sensory skills (crawling, walking, climbing, seeing, hearing)
  • Social-emotional skills (playing, understanding feelings, making friends)
  • Adaptive or self-help skills (eating, bathing, dressing)

Many of the more common therapies, medical and behavioral interventions are listed below.

Therapy interventions:

  • ​Speech Therapy
  • Occupational Therapy
  • Physical Therapy
  • Social/Group Therapy

The below therapies have been recommended by many families, and have shown some degree of success, although there is not a wealth of research to confirm this currently.

  • Hippotherapy (horseback riding)
  • Music Therapy
  • Hydrotherapy (water exercises)

Behavioral Interventions:​

Individuals with Kleefstra Syndrome have can often times be extremely friendly and have a happy disposition based on what many family members and caregivers have reported. At times, they can be overly friendly and ignore typical social boundaries. In addition to this, individuals may experience other behavioral issues such as obsessive-compulsive disorders, aggression towards self or others, anxiety, change resistant with regards to routine, mood swings, and insecurities. Many families have observed an uptick in the problematic behaviors as a child enters puberty. At times, it is necessary to consult a medical professional if behavior issues increase or cause harm. It is advised to make sure the individual is not experiencing a medical/health ailment or lack of sleep before medicating for behaviors.

Medical Interventions:​

Individuals with Kleefstra Syndrome can have complex medical conditions that should be monitored by specialists regularly. These are listed on the symptoms page. ​In addition, individuals may experience sleep pattern disturbances, gastrointestinal conditions, and epilepsy. At times, medication may be prescribed, but should be done so at the hands of a medical professional after close examination and observation. Medication is especially important if an individual is experiencing sleep disturbances causing them to be awake for a period of time longer than 48 hours.
It has also been reported by many families and care givers that special diets can help improve medical and behavior patterns in individuals with Kleefstra Syndrome as they can often times suffer from gastrointestinal conditions.